The Rosetta Design Group performs research and development in computational modeling of macromolecules privately and on a contract basis.

Custom tailored training services with an emphasis on the Rosetta Software Suite are also offerd.

Free support and resources are provided by the Rosetta Commons.

In 1999, a collection of scripts and programs used to predict the tertiary structures of proteins from their amino acid sequences was christened ROSETTA by David Baker and colleagues at the University of Washington in their paper entitled, ‘Ab Initio Protein Structure Prediction of CASP III Targets Using ROSETTA’. The Critical Assessment of Techniques for Protein Structure Prediction (CASP) is a biennial competition of computational protein structure prediction technologies that was established in 1994. In the competition, protein sequences are provided for which crystal structures have been solved but not yet released to the public, eliminating the potential bias that arises from algorithms trained or developed to produce specific structures.

As the Rosetta algorithms and community grew in subsequent years and interests in macromolecular modeling developed beyond structure prediction, Gabrielle Campbell and colleagues at the University of Washington’s Tech Transfer Office worked with the Rosetta developers to establish the Rosetta Commons consortium to allow for continued collaboration. The consortium is governed by an executive committee composed of the principle investigators of each institution. Revenues from licensing Rosetta go directly towards supporting code development by funding RosettaCon and allowing for dedicated support staff. This unique arrangement allows for cutting-edge innovation through combining the strengths of the open source model of development with a coherent organizational structure. As a participating institution in the Rosetta Commons, the Rosetta Design Group is dedicated to serving the Commons through contributions to the development effort and other support.